Figure 4.
(a) TCR residues in contact with mutant TPI. The substituted
TPI isoleucine residue (position 3) is magenta. (b) Interactions
between E8 and mutant TPI. (c) Interactions between the E8 V[
]domain
and the HLA-DR1 1
-helix.
(d,e) Interactions between mutant TPI isoleucine at position 3
and TCR E8 (d) or wild-type TPI threonine at position 3 and
HLA-DR1 complexes (e). TCR residues are identified by one-letter
amino-acid designation followed by position number and chain
designation; peptide residues are identified by one-letter
amino-acid designation followed by position ('P') number. Colors
of TCR and MHC molecules as in Figure 3; hydrogen bonds, red
dotted lines; salt bridges, solid lines; van der Waals contacts,
black dotted lines.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Immunol
(2007,
8,
398-408)
copyright 2007.
]domain
and the HLA-DR1 
1
-helix.
(d,e) Interactions between mutant TPI isoleucine at position 3
and TCR E8 (d) or wild-type TPI threonine at position 3 and
HLA-DR1 complexes (e). TCR residues are identified by one-letter
amino-acid designation followed by position number and chain
designation; peptide residues are identified by one-letter
amino-acid designation followed by position ('P') number. Colors
of TCR and MHC molecules as in Figure 3; hydrogen bonds, red
dotted lines; salt bridges, solid lines; van der Waals contacts,
black dotted lines.