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Figure 4.
Figure 4. (a) Stereo view of MIDAS motif comparison for
ligand-bound and ligand-free conformations. The metal ions are
shown in the same color as the main-chain ribbons, and the water
molecules are in blue. The ligand-free closed conformation, in
the presence of Mg^2+ for α2β1 I-domain (yellow) is superposed
on the ligand-bound open conformation of α2β1 Id-main (cyan)
and the ligand-free open-like conformation of C2a (magenta). A
Glu residue from the ligand collagen completes the coordination
of Mg in α2β1 I-domain open conformation. (b) Stereo view of a
detailed comparison of the MIDAS structures of C2a (magenta)
and Bb (yellow). The metal atom of C2a is shown as a silver
ball and that of Bb is shown as yellow ball. Continuous thin
lines indicate the metal coordination of C2a (magenta) and Bb
(yellow). Water molecules are shown in blue. Figure 4. (a)
Stereo view of MIDAS motif comparison for ligand-bound and
ligand-free conformations. The metal ions are shown in the same
color as the main-chain ribbons, and the water molecules are in
blue. The ligand-free closed conformation, in the presence of
Mg^2+ for α2β1 I-domain (yellow) is superposed on the
ligand-bound open conformation of α2β1 Id-main (cyan) and the
ligand-free open-like conformation of C2a (magenta). A Glu
residue from the ligand collagen completes the coordination of
Mg in α2β1 I-domain open conformation. (b) Stereo view of a
detailed comparison of the MIDAS structures of C2a (magenta) and
Bb (yellow). The metal atom of C2a is shown as a silver ball and
that of Bb is shown as yellow ball. Continuous thin lines
indicate the metal coordination of C2a (magenta) and Bb
(yellow). Water molecules are shown in blue.
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