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Figure 4.
Figure 4 (a) Superposition of the four main DFG conformations
observed in Abl kinase structures, with the active conformation
in cyan, the DFG-out conformation in yellow, the DFG-flip
conformation in grey and the Src-like inactive conformation in
green. (b) Superposition of all structures reported here plus
PDB entry 2g1t . The P-loop is shown in red, the C-helix is
cyan, the A-loop is blue and all the ligands are shown in green.
The superposition is based on an alignment of the C-terminal
lobes to emphasize the relative differences in angles between
the N- and C-terminal lobes of the kinase. (c) A stereoview of
all the ligands superimposed (imatinib, magenta C atoms;
NVP-AFN941, cyan C atoms; NVP-AFG210, yellow C atoms;
NVP-AEG082, green C atoms; PD180970, grey C atoms).
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