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Figure 4.
Figure 4. Pol III PHP Active Site Is Similar to that of DHH
Phosphoesterases
(A) Surface representation showing PHP,
Thumb, and Palm domains (similar view as in Figure 1B). A narrow
groove runs from the Palm domain into a shallow cavity in the
PHP domain that has phosphate bound. (B) Detailed view of
shallow cavity in PHP domain is shown. (C) Active site of
Streptococcus mutans PPase II (Merckel et al., 2001) is shown.
Green sphere indicates a Mg^2+ ion and purple spheres Mn^2+
ions. The overall structure of this protein is unrelated to that
of the PHP domain of Pol III.
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