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Figure 4.
Figure 4. Structure of SplC (red) superimposed on the V8
protease (blue). (a) An overall view of the whole model showing
a high degree of structural similarity. (b) The detailed view of
the active site and specificity region. The structures appear to
be almost identical, except for the Tyr174–Tyr184 loop, which
is β-structured in V8 while flexible in SplC. The “locked”
state of the catalytic His40 is evident.
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