Figure 4 - full size

 

Figure 4.
Figure 4 Superimposed structures of inhibitors in the crystals. Thr1-Lys4 of FR901451 (magenta sticks) bind to PPE in a similar conformation to the linear inhibitor FR136706 (Kinoshita et al., 2003[Kinoshita, T., Nakanishi, I., Sato, A. & Tada, T. (2003). Bioorg. Med. Chem. Lett. 13, 21-24.]; displayed as blue sticks).

The above figure is reprinted from an Open Access publication published by the IUCr: Acta Crystallograph Sect F Struct Biol Cryst Commun (2005, 61, 808-811) copyright 2005.