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Figure 4.
Figure 4. Water molecules form an intricate network of
hydrogen-bonded water molecules across the interface and
water-mediated hydrogen bonds between the NA and Fab. (a) The
water network encircles Glu199. Broken lines are water-water
hydrogen bonds. (b) Schematic of the water interactions in the
interface. The water molecules are identified in magenta, NA
residues are green, antibody H chain residues are dark blue and
L chain residues are light blue. H-bonds are black lines. Direct
contacts between protein residues are shown by broken red lines
to give a sense of the spatial relationships.
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