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Figure 4.
FIGURE 4. G6 bound to VEGF (shown in red) and G6 in its
unbound form (green) superimposed on a number of Fab fragments
in two different views. Shown are B20-4 (yellow), the
Avastin-Fab (blue), and 4D5 (Protein Data Bank code 1FVC, in
white), which adopt canonical conformations, as well as a
selection of Fabs that have non-canonical conformations in
CDR-H2 (Protein Data Bank codes 1IND, 1BBJ, 1FIG, 6FAB, all
shown in white). Note the significant conformational shift of
the G6 CDR-H2 upon VEGF binding.
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