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Figure 4.
Structural characterization of SC-(1-325). A, the two major
helix bundles α[1]^D1-α[3]^D1 (yellow) and α[1]^D2-α[3]^D2
(orange), which are shown superimposed here, are structurally
related. Side chains of all topologically equivalent residues
conserved in both domains are shown with all their non-hydrogen
atoms and labeled. B, close-up of the D1-D2 interdomain
interface, with important residues shown with their full side
chains. Notice the multiple contacts between polar/charged side
chains (e.g. ^SCGlu^54-^SCArg^209), which separate the strictly
conserved ^SCLeu^146 side chain from bulk solvent.
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