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Figure 4.
FIGURE 4. Detailed view of the F3 lobe highlighting the
linker interaction. A, ribbon diagram of the FAK F3 lobe with
the proximal portion of the linker shown in stick form and
colored magenta. The details of this interaction are shown
schematically in panel C. B, the radixin F3 lobe (yellow) bound
to a peptide representing the cytoplasmic tail of ICAM-2 (gray).
C, schematic detailing the interactions of the linker with the
putative ligand binding groove on the F3 lobe. Linker residues
are indicated in magenta, FERM domain residues in cyan. Dashed
lines indicate hydrogen bond interactions and semicircles
indicate hydrophobic interactions. Note that the linker also
contacts the F1 lobe as indicated.
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