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Figure 4.
Figure 4: Summary of experiments on all natural and artificial
WW sequences. a, A pie chart showing the outcomes of folding
studies for natural (n = 42), CC (n = 43), IC (n = 43), or
random (n = 19) WW sequences. Red, natively folded; blue,
soluble but unfolded; yellow, insoluble; grey, poor expressing.
b, Melting temperatures (T[m]) and van't Hoff enthalpies of
unfolding for all folded WW sequences. Open circles indicate
natural sequences and filled circles indicate the 12 folded CC
sequences. The artificial sequences show thermodynamic
parameters that fall into the same range as that of natural WW
domains.
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