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Figure 4.
Figure 4. (a) Binding interactions between two S1s
molecules and the Grb2 SH2 domain in the C site, green and
orange, and D site, cyan and yellow ball-and-stick models. (b)
Stereo view of the superposition of Grb2 SH2 ligands from PDB
entries 1ZFP (magenta), 1FYR (gold), 1BM2 (cyan), 1TZE (slate
blue), and 1CJ1 (tomato) on subunit A S1s (green). The carbon
atoms of the S1s-binding residues in ball-and-stick are grey and
the ligands are in bonds. Hydrogen bonds are shown in red broken
lines for S1s. Superposition of all 12 S1s molecules in stereo
showing different side-chain rotamers and conformational changes
derived from binding in the various pockets of the
domain-swapped dimer. (c) Those that bound in the A site are in
black, B site in dark green, C site in orange and red, and D
site in blue and cyan.
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