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Figure 4.
Figure 4: The NS5A domain I dimer reveals potential interaction
surfaces. a, Ribbon diagrams of three rotations of the domain
I dimer. b, Surface-potential plots of the domain I dimer, with
views corresponding to those shown in a. Analysis of images in a
and b shows that the dimer creates a relatively flat, basic
surface near the N terminus and a large groove between the two
subdomain IB regions. c, Model of NS5A position relative to the
endoplasmic reticulum membrane. The location of the conserved
surface in Fig. 3b is indicated. Helices are from the recent
structure of the NS5A N-terminal helix8.
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