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Figure 4.
Figure 4. Comparison of WW and SH3 domain complexes. (a)
Schematic representation of a WW domain showing important
regions for ligand recognition. Residues conserved for all WW
domains are displayed in blue. Positions changing between the WW
domain specificity classes are shown in green, next to which the
amino acid types and their corresponding WW domain classes are
indicated in parentheses. Superposition of FBP11WW1 (grey
ribbon, blue side-chains, class II) complexed to APPTPPPLPP
(cyan) with: (b) dystrophinWW domain (red, class I) in complex
with SPPPY (yellow); (c) Pin1WW domain (red, class IV): in
complex with (poS)PT(poS)PS (yellow); and (d) the C-CRK
N-terminal SH3 domain (red) in complex with PPPALPPK (yellow).
(e) PRP40WW1 (red, class II) and (f) PRP40WW2 (red, class II)
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