Figure 4.
Figure 4. DC-SIGN and DC-SIGNR interactions with Lewisx and
oligomannosides. (a) DC-SIGNR bound to Lewisx trisaccharide.
(b) DC-SIGN bound to LNFP III. In a and b, key residues that
differ between DC-SIGN and DC-SIGNR are shown. (c) Comparison of
Man[4] (yellow bonds) binding with GlcNAc[2]Man[3] (red
bonds)14. Phe313 interacts with the Man 1-6Man
moiety of the trimannose structure. (d) Comparison of Man[4]
(yellow bonds) and LNFP III (black bonds) bound to DC-SIGN. The
color scheme is the same as in Figure 3.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2004,
11,
591-598)
copyright 2004.
1-6Man
moiety of the trimannose structure. (d) Comparison of Man[4]
(yellow bonds) and LNFP III (black bonds) bound to DC-SIGN. The
color scheme is the same as in Figure 3.