|
Figure 4.
Figure 4. The active site of the RT(P) -tenofovir complex with
tenofovir in two conformations. In one conformation
(tenofovir I), tenofovir stacks with the penultimate primer
residue but does not engage in Watson-Crick base-pairing with
the template dTMP. The dashed lines for the two base pairs
upstream of the 3' terminus are labeled 1 -3 and 1' -3' for the
template and primer strands, respectively. In the second
conformation (tenofovir II), the adenine of tenofovir is flipped
out by ~180° relative to the position of adenine in the first
conformation.
|
