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Figure 4.
Figure 4 Minor groove interactions are lost in furan-containing
DNA. (A) Minor groove interactions in the active site of ternary
complex (1IG9; Franklin et al, 2001). Hydrogen bonds are shown
as dashed red lines. For clarity only the bases of the primer
strand are shown. (B) Pol1, in the same orientation as the
ternary complex in (A). All minor groove interactions seen in
the ternary complex are lost. (C) Pol2, in the same orientation
as in (A) and (B). The DNA shifts further away from the palm
domain.
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