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Figure 4.
Figure 4. The Nonprolyl cis Peptide Bond in AdfThe
nonprolyl cis peptide bond between Cys72 and Ile73 is an
essential constituent of a bulge that is directed toward the
F[420] binding site, causing a bent conformation of the
deazaisoalloxazine ring. The well-conserved Asp38, which would
partly interfere with a straight course of strand b3, is
strongly linked to the polypeptide chain and stabilizes the
bulge. These favorable interactions might compensate for the
energy lost when forming the nonprolyl cis peptide bond.
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