Figure 4.
FIG. 4. The proposed mechanisms for catalysis (A) and metal
attenuation (B). The numbers shown indicate the interatomic
distances in angstroms. Asp366 maybe with assistance from His67
and His69, is responsible for the proton transfer from the water
molecule to the amide nitrogen (3). The presence of the
inhibitory metal ion at the [1] site might lower
the pK[a] values of its ligand residues, His67, His69, and
Asp366, and/or hold the active site water to perturb the proton
shuttle and intermediate stabilization.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2004,
279,
13962-13967)
copyright 2004.
[1] site might lower
the pK[a] values of its ligand residues, His67, His69, and
Asp366, and/or hold the active site water to perturb the proton
shuttle and intermediate stabilization.