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Figure 5.
Figure 5. Model of Ins(1,3,5)P[3] in the Active Site of
MTMR2(A) A schematic of the phosphate molecules and hydrogen
bond network in the MTMR2 active site. Hydrogen bonds are shown
as blue dotted lines.(B) Model of Ins(1,3,5)P[3] in the active
site of MTMR2 with its D1 and D3 phosphate groups superimposed
onto the phosphate molecules shown in (A).(C) Phosphatase
activity of MTMR2 mutants toward PI(3)P and PI(3,5)P[2]
substrates. Values are expressed as percent wild-type MTMR2
activity of three independent experiments (mean ± SEM).
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