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Figure 4.
Figure 4 Close-up on ATP binding by mNBD1. (A) Canonical
hydrogen bonding interactions in Mg-ATP mNBD1. Some relevant
hydrogen bonds are indicated as green lines. Some residues in
the foreground and background have been removed to clarify the
interactions, here and in (B) and (C). (B) Differences in
adenine base recognition from other ABC domains. Left: adenine
stacks against Tyr11 of MJ0796 (PDB ID code 1L2T). Right:
adenine of ATP makes edge-to-face interactions with Phe430 of
mNBD1. (C) Added structure in phosphorylated mNBD1. The ATP
molecule plus magnesium in blue, the additional mNBD1 residues
observed in the phosphorylated state in white, the phosphate
atoms of Ser422 and Ser660 in brown, and the remainder of the
mNBD1 structure in yellow are shown.
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