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Figure 4.
FIG. 4. Conformation of LXCXE motifs. Shown is the HPV E7
peptide bound to the pocket domain of Rb (A) and gankyrin (B).
In A all the Rb protein atoms are colored in pink with the HPV
E7 peptide atoms colored according to element. The Leu, Cys, and
Glu side chains of the E7 peptide are buried by their
interaction with Rb. In B, gankyrin atoms are colored pink
except for those of Leu178, Cys180, and Glu182, which are
colored by element. The Cys180 side chain is buried in the
protein core.
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