|
Figure 4.
Figure 4. Diagram showing the binding of (a) AMP-PNP, (b)
staurosporine, (c) indirubin-3-monoxime and (d) alsterpaullone
to GSK-3b. Residues playing a direct or indirect role in
inhibitor binding are shown in a ball-and-stick representation.
Inhibitor molecules are shown in tan; water molecules and Mg2+
are shown in red and yellow, respectively. The C^a trace of
GSK-3b is shown in blue and green for the N- and C-terminal
domains, respectively. To avoid "cluttering" in the AMP-PNP
diagram, the two water molecules coordinating Mg1 are omitted
and Asp200, the residue coordinating Mg1 and Mg2, is unlabelled.
|
