Figure 4.
FIG. 4. Thrombin and its interactions with inhibitors. a,
superposition, in stereo, of thrombin or S195A thrombin
structures of complexes with PPACK (gold) (Protein Data Bank
code 1HAI [PDB]
), with BPTI (green) (Protein Data Bank code 1BTH [PDB]
), and with heparin cofactor II (red) (Protein Data Bank code
1JMO [PDB]
), showing the identical conformations of all regions except the
surface loops flanking the active site, particularly the 60 loop
and 150 loop. b, stereo representation of the P5-P5' residues of
[1]PI Pittsburgh (cyan)
from the noncovalent complex with S195A trypsin docked into the
thrombin structure found in the noncovalent complex of S195A
thrombin with heparin cofactor II (HCII in magenta).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2003,
278,
37881-37887)
copyright 2003.
[1]PI Pittsburgh (cyan)
from the noncovalent complex with S195A trypsin docked into the
thrombin structure found in the noncovalent complex of S195A
thrombin with heparin cofactor II (HCII in magenta).