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Figure 4.
Figure 4. Surface Patches within the Concave Face of NgR(A)
Space-filling model of the concave face showing the two surface
clusters enriched in aromatic side chains that are coincident
with the conservation analysis, and a very prominent acidic
cavity situated at the periphery of the groove that likely
mediates specificity contacts through hydrogen bonding (Trp,
Phe, and Tyr in green; His in purple; acidic residues in
yellow).(B) Hydrophobic patch #1 on the upper side of the
concave surface, centered at Trp87, Phe63, and Ile85.(C) The
acidic patch. Three aspartic acid side chains surround Ser113,
forming a depressed acidic region.(D) Hydrophobic patch #2 on
the lower side of the concave surface, centered at Phe184 and
Leu208.(E) The hydrophobic cavity located at the LRRCT
domain.(F) Crystallographic interaction utilizing the LRRCT
hydrophobic cavity.
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