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Figure 4.
Figure 4 Actin -CapZ interaction. (A) Surface representations of
an actin filament model (Lorenz et al., 1993), viewed from two
different directions. In the left panel, the filament axis runs
across and oblique to the plane of the page with the barbed end
in the foreground, while in the right panel, the axis runs on
the plane. The cones at the sides of the filaments indicate the
filament orientations with the apex and the base indicating the
pointed and barbed ends, respectively. One of the two actin
molecules at the barbed end is colored in pink, and the
hydrophobic residues on its surface are in yellow. The
hydrophobic patches are highlighted with circles. The other
actin molecule at the end is colored in cyan. The molecular
surface of CapZ is also shown on the same scale, with the pair
of C-terminal extensions [residues  (260-C-terminus)
and  (245-C-terminus)]
in red, and the N-terminal domains (residues (N-terminus-115)
and (N-terminus-86)]
in gray. (B) Schematic drawings of the possible binding modes of
capping protein to the actin filament (speculative models).
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