Figure 5.
Figure 5. Stabilizing Interactions at the Base of the Hinge
Loop(A) Residue contacts within E6AP in the L shape
conformation. Lys549 interacts with Asn822, Gln553 hydrogen
bonds with Thr819, and Asp607 appears to interact with
His609.(B) Residue contacts within WWP1/AIP5 in the shape
conformation. Arg613 interacts with Gly610, and His621 hydrogen
bonds with Asp675. Both pairs of interactions bridge the H3
helix to loop regions (S2/H3 and H4/H5 loops).(C) WWP1/AIP5
(residues 546–922) was used as a reference for wild-type
autoubiquitylation activity.
The above figure is reprinted
by permission from Cell Press:
Mol Cell
(2003,
11,
249-259)
copyright 2003.
shape
conformation. Arg613 interacts with Gly610, and His621 hydrogen
bonds with Asp675. Both pairs of interactions bridge the H3
helix to loop regions (S2/H3 and H4/H5 loops).(C) WWP1/AIP5
(residues 546–922) was used as a reference for wild-type
autoubiquitylation activity.