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Figure 4.
Figure 4. Structure of the Methyltransferase Active Site(A)
Stereo ribbon diagram showing the F[o] - F[c] difference density
(magenta) observed in the active site of the AdoHcy-bound
MT0146/CbiT crystal form with molecular replacement phases
calculated from the apo model. The electron density was
contoured at 3.5 s. The coordinates of the AdoHcy molecule shown
in ball and stick representation came from the structure of the
COMT homolog [12] on the basis of the structural alignment of
its methyltransferase fold to that of MT0146/CbiT by the program
DALI.(B) Stereo pair showing the binding contacts to the AdoHcy
molecule in the refined MT0146/CbiT complex structure.
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