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Figure 5.
Figure 5. Model of ICAT as a Bipartite Transcriptional
InhibitorOn the left, transcription activation complexes
consisting of β-catenin, Tcf/Lef, and CBP/p300 are bound to
cognate DNA sites through interaction of the Tcf/Lef HMG box.
Binding of ICAT to β-catenin simultaneously displaces CBP/p300
and Tcf/Lef, allowing for Groucho/TLE repressor proteins to bind
to Tcf/Lef.
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