Figure 4 - full size

 

Figure 4.
Fig 4. (Upper) Detail of the Crk SH2 domain bound to the Crk phosphopeptide (residues 221-224) in the ternary complex. Residues observed to make contacts are highlighted. (Lower) Sequence comparison of Crk-II with homologues v-Crk and CrkL. The sequence of murine Crk-II corresponds to the protein fragment described in this study. Only Crk-II contains a binding site for the Abl SH3 domain (shaded box).