Figure 4 - full size

 

Figure 4.
Figure 4. A stereo view close-up of the trench showing residue His 154 and its neighboring residues around the active site. Residues Tyr 150, His 151, Asp 152, Tyr 452, Tyr 538 and Asp 540 all may contribute to the mRNA decapping reaction. The four loops corresponding to loop 1, 2, 3 and 4, are colored in red, green, blue and pink, respectively.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Biol (2002, 9, 725-728) copyright 2002.