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Figure 4.
Fig 4. Interfacial interactions between CN and
immunophilins-immunosuppressants. CNA and CNB are shown as
yellow and cyan ribbons. (A) The CN composite surface for
CyPA-CsA binding. A total of 25 residues of CN are involved in
interaction with CyPA-CsA: Arg-122, Tyr-159, Phe-160, Leu-312,
Val-314, Tyr-315, Tyr-341, Trp-342, Pro-344, Asn-345, Trp-352,
Ser-353, Pro-355, Phe-356, and Glu-359 of CNA, and Glu-47,
Gln-50, Met-118, Val-119, Asn-122, Leu-123, Lys-124, and Lys-164
of CNB. Red balls represent residues interacting with CyPA and
green balls represent residues interacting with CsA (green
sticks). The residues from CNB are marked with the letter "B"
attached to the residue number. (B) The CN surface for binding
of CyPA-CsA and FKBP12-FK506. CN residues in red interact with
both CyPA-CsA and FKBP12-FK506. Green residues are unique for
CyPA-CsA binding and blue residues are unique for FKBP-FK506.
CsA and FK506 are shown as green and blue sticks. (C) CyPA
residues for recognition of CN (gold) and CsA (blue). CsA is
shown in green sticks.
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