Figure 4 - full size

 

Figure 4.
Fig. 4. The LVI tripeptide segment of EGFRK is found in close association with the C-lobe. A solvent-accessible surface from EGFRK with LVI removed is depicted. Residue Leu955, the most important as gauged by mutagenesis studies, is found within what in its absence would be a hydrophobic pit.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2002, 277, 46265-46272) copyright 2002.