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Figure 4.
Fig. 4. Stereo ribbon diagram of the hypothetical model
of complex formed between proMMP-2, TIMP-2, and the catalytic
domain of MT1-MMP. In the model shown, TIMP-2 is a hybrid with
its C-terminal domain taken from the presented proMMP-2/TIMP-2
complex structure (magenta) and the N-terminal TIMP-2 half (red)
is obtained from the model of the MT1-MMP/TIMP-2 inhibitory
complex (Protein Data Bank code 1BUV) (26). Such combining was
done because of the structural differences between complexed and
uncomplexed forms of TIMP-2 molecules. Coloring for proMMP-2:
the propeptide is pink, catalytic domain is blue, three
fibronectin-like domains are green, and the hemopexin domain is
yellow; for MT1-MMP: the catalytic domain is light blue.
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