Figure 4.
Figure 4. Mutations Mapped onto Surface of Site 2Left:
surface of CR1 vert,
similar 15–17 using color scheme (red, 15; cyan, 16; blue,
17), except where mutagenesis yielded no significant loss of C3b
(iC3) binding or C4b binding (black), some loss of C3b (iC3)
binding (aa 937, 1053) or C4b binding (aa 927, 929, 1046)
(yellow), or major loss of C3b and/or C4b binding (white).
Single asterisk indicates residues that, when incorporated at
their equivalent positions in site 1 (i.e., D109N, N29K, and
T14K), caused gain of C3b binding. Double asterisk indicates two
residues (Y27S/G79D) that confer C3b binding activity when
simultaneously inserted at their equivalent positions in site
1.Right: same features but rotated (about vertical axis) by
180°.
The above figure is reprinted
by permission from Cell Press:
Cell
(2002,
108,
769-780)
copyright 2002.
vert,
similar 15–17 using color scheme (red, 15; cyan, 16; blue,
17), except where mutagenesis yielded no significant loss of C3b
(iC3) binding or C4b binding (black), some loss of C3b (iC3)
binding (aa 937, 1053) or C4b binding (aa 927, 929, 1046)
(yellow), or major loss of C3b and/or C4b binding (white).
Single asterisk indicates residues that, when incorporated at
their equivalent positions in site 1 (i.e., D109N, N29K, and
T14K), caused gain of C3b binding. Double asterisk indicates two
residues (Y27S/G79D) that confer C3b binding activity when
simultaneously inserted at their equivalent positions in site
1.Right: same features but rotated (about vertical axis) by
180°.