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Figure 4.
Figure 4. Superposition of the Elk-1 DNA recognition helix
onto the ternary SAP-1/SRF/c-fos SRE DNA complex. The DNA
recognition helix of Elk-1 is shown in aqua with the relative
orientation of the three corresponding side chains (yellow) that
have the most divergent orientation when compared to SAP-1 in
either the binary or ternary complex. This superposition
suggests that the presence of SRF may induce these residues of
Elk-1 to take on a SAP-1 like conformation within a ternary
Elk-1/SRF/c-fos SRE DNA complex and thus facilitate Elk-1
binding to a c-fos SRE DNA sequence.
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