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Figure 5.
Figure 5. PtdIns(3)P Bound to the p40^phoxPX Domain(A)
σ[A]-weighted electron density for the di-C4-PtdIns(3)P and
some of the surrounding amino acids. The 2mF[o]-DF[c] map was
contoured at 1 σ and rendered with BOBSCRIPT (Esnouf, 1999).(B)
A view of the PtdIns(3)P binding pocket. Interacting residues
are drawn as cyan sticks, and hydrogen bonds are shown by dashed
lines. The inositol ring also makes hydrophobic contacts with
the side chain of Tyr59, and the diacylglycerol moiety makes
hydrophobic contacts with the side chain of Tyr94. In addition,
the Arg57/Asp139 salt link is shown
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