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Figure 4.
Figure 4. The electron density for each of the ALAD
ligands bound to Lys263: (a) substrate ALA at 1.7 Å res-
olution; (b) laevulinic acid (LA) at 1.6 Å resolution; (c)
succinylacetone (SA) at 2.0 Å resolution; and (d) 4-keto-
5-amino-hexanoic acid (KAH) at 1.64 Å resolution. All
maps are contoured at 1.0 rms. The Lys263 side-chain
can be seen behind the inhibitor moiety. The two confor-
mers adopted by ALA and LA are coloured slightly
different shades of green in (a) and (b).
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