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Figure 4.
Figure 4. The δ′ Stator Is Unlikely to Cause Closure of
the Adjacent γ1 ATP Binding SiteOn the left, the γ1 (green)
and γ2 (red) pair of subunits is shown, with Sensor 1 of γ1
(magenta) positioned near the ATP binding site of γ2 (indicated
in gray). The first helix of Domain III of γ1, α10, is shown
as a magenta tube to highlight the flexible linker connecting it
to the last helix of Domain II. On the right, γ2 is shown
again, in the same orientation as on the left (red). The γ1
subunit is replaced by δ′ (orange), which has been
superimposed on γ1 using the C-terminal domain. Note that helix
α10 in δ′ is extended at its N terminus relative to the
structure seen in γ1, so that the connection to Domain II no
longer appears to be flexible. The overall conformation of δ′
is more closed than that of γ1, so that the Sensor 1 region of
δ′ is no longer located as close to the ATP binding site of
γ2 as that of γ1
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