Figure 4 - full size

 

Figure 4.
Figure 4. Stereoview of the superimposition of TMC-95A and epoxomicin (including the Thr1 as a morpholino-ring adduct), with respect to subunit b2. TMC-95A is shown in yellow, epoxomicin is drawn in green and the active site Thr1 in black. The superimposition clearly indicates that the S1 and S3 pockets are occupied in a unique way by the corresponding residues of the inhibitors (blue ellipsoids).

The above figure is reprinted by permission from Elsevier: J Mol Biol (2001, 311, 543-548) copyright 2001.