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Figure 4.
Figure 4. Cooperative Structural Interactions Involving
Phylogenetically Conserved Residues Stabilize Limiting
Conformations of the g-Phosphate LinkerH bonds in the
g-phosphate linker region identified based on having a
heteroatom separation =< 3.4 Å are represented by dotted orange
lines in the stereo pairs [57 and 58] showing:(a) The ATP-bound
structure of HisP [16].(b) The Mg-ADP-bound structure of MJ0796
[21].(c) The Mg-ADP-bound structure of MJ1267.(d) One of the two
NCS-related molecules in the pyrophosphate-bound structure of
MalK [17].Residues with side chains participating in alternative
H bonding networks with phylogenetically conserved Arg166 are
shown in cyan. Relative to MJ1267, homologous residues in the
g-phosphate linker region are offset by +1 in MJ0796, +11 in
HisP, and -1 in MalK, and homologous residues in the C terminus
of the ABCa subdomain are offset by -8 in MJ0796, +0 in HisP,
and -14 in MalK
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