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Figure 5.
Figure 5. Comparison of Ligand Binding Sites on LIR-1 D1D2
and KIR2DL1(A) Residues altered by site-directed mutagenesis are
highlighted on a ribbon diagram of the LIR-1 D1D2 structure.
Alteration of residues indicated in red resulted in changes in
the affinity of LIR-1 D1D2 or LIR-2 D1D2 for UL18 (Table 2).
Alteration of residues indicated in blue had no significant
effect on the binding affinity.(B) Residues contributing to the
KIR binding site for class I MHC molecules ([4, 42, 38, 43 and
6]) are highlighted on the structure of KIR2DL1 ( [16]).
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