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Figure 4.
Figure 4. Interaction of the Pol Peptide with UL42The
peptide is folded into an αβα structure on the front surface
of UL42. (A) Ribbon diagram of UL42 (blue) bound to peptide A
(orange) (UL42 is oriented as in Figure 2). (B) Molecular
surface representation of UL42 with peptide A bound. P1 and P2
denote pockets formed on the surface of the molecule. Labeled
residues belong to the peptide, except for that of UL42 Q171,
which is labeled as a projection on the surface. The side chains
of the peptide are colored as follows: blue, K, R, and H; red, D
and E; yellow, G; magenta, A; cyan, T; and white, L, V, and F.
(C) Schematic representation of the intermolecular hydrogen
bonds between the peptide (orange) and UL42 (blue). Spheres
represent the alpha carbons. The cylinders represent the two
helices of the peptide, and the arrows indicate the region of
Pol and UL42 that form the antiparallel β strands.
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