Figure 4 - full size

 

Figure 4.
Fig. 4. Stereo comparison of 2.5 Å di-Zn-DF1 structure with designed model. The superposition of the crystal structure symmetric dimer (green) and the designed model (gray) shows the liganding Glu and His residues. Note that the dimetal-binding site is nearly identical between the model and the crystal structure. However, conformation of the Tyr-2 and Trp-42 side chains in the crystal structure differs markedly from that in the design.