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Figure 4.
Figure 4. Mapping of the Different Interaction Sites onto
the Molecular Surfaces of FGF2 and FGFR1The surface color
codings for D2, D3, the linker, and FGF2 are the same as in
Figure 1. The surfaces of FGF2 and FGFR1 that form the primary
and secondary interaction sites are shown in red and purple,
respectively. The heparin-binding surfaces are depicted in blue.
The surface on D2 engaged in direct receptor–receptor
interaction is colored yellow. To better visualize the different
functional surfaces on FGF2 and D23, the two molecules are
pulled away from each other and rotated 90° about the
vertical axis. This figure was created using the program GRASP (
[33]).
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