|
Figure 4.
Figure 4. Interdependence of the Conformations of Helix αC
and the Activation SegmentThe catalytic domain of inactive Hck
is shown superimposed on that of active Lck ([45]) (A) and of
inactive Cdk2 (B) ( [6]). The structural alignments are based on
the C-terminal lobe in (A) and on the β strands in the
N-terminal lobe of the kinase domains in (B). Helix αC (α1 in
Cdk2) and the activation segment are colored in blue, red, and
green for Hck, Lck, and Cdk2, respectively. The figure was
generated using RIBBONS ( [5]).
|
