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Figure 3.
Figure 3. The structure of the inter-molecular V[L]
-V[L]dimer seen in CAMH. A complete Fab is shown with the
V[L]and C[L]domains in green and the V[H]and C[H]domains in
yellow. In cyan is shown the V[L] domain of an adjacent molecule
at position ( -y, -x 1/6 - z), related by a vertical
crystallographic 2-fold axis lying approximately in the plane of
the paper. The side-chains ArgL18 and AspL70', which make a
symmetrical pair of salt-bridges, are labelled. There is also a
hydrogen bond between ArgL18 and SerL7'. The antiparallel
interaction between the first b-strands of the two V[L] domains,
showing the extent of the intermolecular hydrogen bonding
between residues L9-L12, viewed from the outside of the dimer
towards the interface is shown in detail (RIBBONS; [Carson
1991]).
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