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Figure 3.
Figure 3 Conserved hydrogen-bond networks by the second and
third ankyrin repeats of p16 and p19 have a central role in Cdk6
binding. a, Cross-section of the complex showing the contacts
between Cdk6 and the second ankyrin repeat. b, Cross-section
showing the third ankyrin repeat. Only the hydrogen-bond
contacts conserved in the p16-Cdk6 and the p19-Cdk6 complexes
are shown (red dotted lines). The figures show the p19-Cdk6
complex, as the atomic positions of this 2.8-?-refined model are
of higher precision than those of the 3.4-?-refined p16-Cdk6
complex. INK4 residues are labelled first with their p19 numbers
and second with their p16 numbers, separated by a slash. The
secondary structure labels of Cdk6 are according to Cdk2 (ref.
30).
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