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Figure 3.
Figure 3. RyR2 A77V and V186M Mutations Cause Distinct
Changes in the Surface
(A) Superposition of RyR2 wild-type
(blue) and RyR2 A77V (orange) in the region surrounding the
mutation. Nitrogen atoms are shown as dark blue, oxygen in red,
and sulfur in yellow. The inset shows the view (box) relative to
the full domain.
(B) Superposition of RyR2 wild-type (blue)
with RyR2 V186M (brown).
(C and D) Surface representation
of RyR2 wild-type (blue) with the surface of the superposed A77V
and V186M mutations shown as a mesh. The views are identical to
the ones for the corresponding Figures 3A and 3B. The A77V and
V186M mutations alter the local surface. Numbers shown are
solvent accessible areas, with the first number for the
wild-type residue, and the second for the mutant.
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