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Figure 3.
Electrostatic surface potential of the two Brd4 bromodomains.
Displayed is the electrostatic surface potential from −15
k[B]T (red) to +15 k[B]T (blue) for BD1 (A) and BD2 (B). The
binding site for acetylated lysines is indicated by arrows.
Acidic residues on helices α[Z″] to α[A] and the BC loop
form negatively charged surfaces surrounding the interaction
cleft of both bromodomains (right panel).
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